Lab of GPCR Expression and Signal Transduction (L-GEST)

Department of Biochemistry and Microbiology
Faculty of Sciences
Ghent University

Prof. Dr. Kathleen Van Craenenbroeck

group leader GPCR

My general research interests are G protein-coupled receptors. The goal of our studies is to understand the molecular mechanisms that control the efficacy and the selectivity of GPCR signalling. Thereto several projects aim at describing, on a molecular level, the link between ligand binding and signalling efficacy in specific pathways. We study regulatory processes such as receptor phosphorylation, ubiquitination and endocytosis controlling responsiveness. In addition, we analyse and try to define the role of protein-protein interactions.


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